Skinnymaxxing
Skinnymaxxing is the combined fat-loss shelf: every GLP-class incretin receptor agonist alongside the metabolic-mechanism compounds that act through separate pathways. The GLP entries are grouped by receptor tier — mono-agonist (GLP-1), dual (GLP-1/GIP), and triple (GLP-1/GIP/glucagon). The metabolic entries are grouped by mechanism of action: mitochondrial uncouplers, AMPK activators, lipolysis modulators, amylin analogues, and myostatin inhibitors. Every entry is presented for educational reading of the published pharmacology and supplied for laboratory research use only, priced per vial with a lot-matched Certificate of Analysis confirming \u226598% HPLC purity. Several molecules below are investigational or prescription-only drugs; nothing here is medical advice or a recommendation for personal use.
Triple Agonist
GLP-1 · GIP · Glucagon
Retatrutide (investigational)
Dual Agonist
GLP-1 · GIP
Tirzepatide
Mono Agonist
GLP-1
Semaglutide
Tier 1 · GLP-1 + GIP + Glucagon
Triple Agonist
Investigational triple incretin receptor agonists studied in Phase 3 research.
Receptor class
GLP-1 / GIP / glucagon receptor agonist

Retatrutide 10mg
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Tier 2 · GLP-1 + GIP
Dual Agonist
Dual incretin receptor agonists characterized in the clinical literature.
Receptor class
GLP-1 / GIP receptor agonist

Tirzepatide 15mg
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CAS: 2023788-19-2

Mazdutide 6mg
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CAS: 2259320-21-7

Survodutide 10mg
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CAS: 2230198-02-2
Tier 3 · GLP-1 only
Mono Agonist — GLP-1
First-generation single-receptor incretin mimetics.
Receptor class
GLP-1 receptor agonist

Semaglutide 12mg
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Tier 4 · Amylin receptor + co-administered GLP
Amylin / Co-Agonist
Amylin-pathway analogues referenced alongside GLP-class compounds in research.
Receptor class
Amylin receptor analogue
Other GLP-Class Compounds
Blended formulations and research variants outside the main agonist tiers.

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Mechanism Comparison
| Class | Pathway | Key Examples | Half-Life | Products |
|---|---|---|---|---|
UCPMitochondrial Uncoupler | Dissipates proton gradient → heat, raising basal metabolic rate | BAM-15, 2,4-DNP analogs | 4–8 hours | 2 |
AMPKAMPK Activator | Mimics cellular low-energy state → fatty acid oxidation | 5-Amino-1MQ (NNMT inhibitor) | 12–16 hours | 3 |
LIPLipolysis / β-Oxidation | HSL activation, fat mobilization without affecting IGF-1 | AOD-9604, Adipotide | 30 min – 2 hours | 5 |
AMYAmylin / Satiety | Amylin-receptor signaling; gastric-emptying and satiety pathways in preclinical models | Cagrilintide, Amycretin | 7+ days (long-acting) | 0 |
MYOMyostatin / Growth-Axis | Myostatin-pathway inhibition; studied for lean-mass preservation in preclinical models | ACE-031, Follistatin-344 | varies | 0 |
Mitochondrial Uncoupler
Dissipates proton gradient → heat, raising basal metabolic rate
Half-life 4–8 hours
AMPK Activator
Mimics cellular low-energy state → fatty acid oxidation
Half-life 12–16 hours

5-Amino-1MQ 50mg
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CAS: 104819-09-2
Lipolysis / β-Oxidation
HSL activation, fat mobilization without affecting IGF-1
Half-life 30 min – 2 hours

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Other Metabolic Compounds
Metabolic modulators outside the main mechanism classes.

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