SNAP-8 10mg

Name: SNAP-8 10mg
Brand: Phiogen
SKU: PG-1109
Price: 45 USD
Availability: InStock

Acetyl Octapeptide-3 (SNARE complex inhibitor)

CAS: 868844-74-0

SNAP-8 (Acetyl Octapeptide-3) — Clavicular's KLOW peptide. SNAP-25 NMJ analog studied for expression wrinkle reduction. Up to 63% wrinkle depth reduction in preclinical models.

≥98% Purity

HPLC Verified

Research Grade

Lyophilized

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For research purposes only. Not intended for human use.

SNARE Complex Competition at the Neuromuscular Junction

SNAP-8 (acetyl octapeptide-3, CAS: 868844-74-0) is a synthetic SNAP-25 N-terminal analog. SNAP-25 is a component of the SNARE complex — the molecular machinery that enables acetylcholine vesicle fusion at the neuromuscular junction. SNAP-8 competes with endogenous SNAP-25 for SNARE complex binding sites, partially inhibiting ACh release efficiency at the NMJ. Lower ACh release reduces the force of facial expression muscle contractions — attenuating the repeated mechanical stress on overlying skin that deepens dynamic wrinkles.

KLOW Protocol — Expression Wrinkle Research

Dynamic wrinkles (crow's feet, forehead lines, glabellar lines) deepen through repeated expression muscle contraction. SNAP-8 research models partial NMJ inhibition to attenuate this mechanism. Preclinical models showed up to 63% wrinkle depth reduction.

Different Mechanism from GHK-CU

GHK-CU addresses structural skin biology — collagen matrix, fibroblast activity, angiogenesis. SNAP-8 addresses neuromuscular dynamics — ACh at the NMJ. Completely orthogonal pathways. Running both (GLOW + KLOW) covers both structural and dynamic dimensions of skin quality.

Partial NMJ Inhibition

Unlike botulinum toxin (complete NMJ blockade), SNAP-8 models partial, competitive inhibition. SNARE complex function is preserved but with reduced ACh release amplitude — maintaining expression while reducing the mechanical force applied to skin.

Specifications

Chemical NameAcetyl Octapeptide-3 (Acetyl Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2)

CAS Number868844-74-0

FormLyophilized powder

Purity≥98% (HPLC verified)

Reconstitution5mL BAC water → 1mg/mL

Storage−20°C long-term / 4°C up to 4 weeks reconstituted

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Research FAQ

What is the KLOW peptide?

SNAP-8 (acetyl octapeptide-3) — Clavicular's name for the neuromuscular skin layer. It's a SNAP-25 analog that partially inhibits ACh release at the NMJ, reducing expression muscle contraction force and the deepening of dynamic wrinkles.

Can SNAP-8 be used topically?

SNAP-8 has been studied both as an injectable and as a topical preparation (0.1-2% in carrier). As a research compound, both routes have published data. The injectable form provides more precise dosing control.