Lean Mass & Longevity
CJC-1295/Ipamorelin for GH-driven lean mass preservation and Epithalon for telomere/longevity research.
Mechanism of Action
GHRH Receptor (CJC-1295)
CJC-1295 No DAC binds GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH release with ~30 minute half-life. Preserves natural GH pulsatility — key for anabolic effects.
Ghrelin Receptor (Ipamorelin)
Ipamorelin selectively activates GHS-R1a with high selectivity — no cortisol or prolactin elevation. Combined with CJC-1295 (GHRH analog), produces synergistic pulsatile GH release.
Telomerase Activation (Epithalon)
Epithalon activates telomerase in somatic cells — rare among non-cancer cells. Extended telomeres correlate with cellular longevity markers in Khavinson's aging research.
Products in This Layer
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Lean Mass & Longevity
The full Clav stack extends beyond the core three compounds into lean mass preservation and cellular longevity research.
CJC-1295/Ipamorelin: Lean Mass
Dual GH secretagogue combination:
- CJC-1295 (No DAC): GHRH analog — stimulates pulsatile GH release from the pituitary
- Ipamorelin: selective GHRP — activates ghrelin receptor for additive GH secretion without cortisol or prolactin elevation
Teichman et al. 2006: CJC-1295 produced 2-10x GH increase and sustained IGF-1 elevation for 6-9 days from a single dose.
Epithalon: Longevity Layer
Epithalon (Ala-Glu-Asp-Gly) is a tetrapeptide studied for telomerase activation and pineal gland support. From Khavinson's 50+ year research program at the St. Petersburg Institute of Bioregulation.
Key research areas:
- Telomerase activation in somatic cells
- Normalization of circadian rhythm via melatonin regulation
- Antioxidant properties in aging models
Frequently Asked Questions
Why add CJC-1295/Ipamorelin to a GLP stack?
GLP peptides at high doses can produce lean mass loss alongside fat loss. CJC-1295/Ipamorelin research investigates whether GH secretagogue co-administration preserves lean tissue during GLP-driven caloric restriction. The combo provides pulsatile GH elevation without cortisol elevation.
What is Epithalon?
Epithalon (Ala-Glu-Asp-Gly) is a tetrapeptide studied for telomerase activation and pineal/melatonin support. From Khavinson's research program spanning 50+ years. Used as the longevity layer in the advanced Clav stack.
Build the Clav Stack
Research-grade compounds from Apollo Peptide Sciences. The Official Protocol. The Only Stack.